Medical Studies

Calcium supplements: practical considerations
Osteoporos Int. 1991 Feb;1(2):65-71.
Heaney RP

Factors influencing the measurement of bioavailability, taking calcium as a model.
J Nutr. 2001 Apr;131(4 Suppl):1344S-8S.

Daily vitamin K supplementation improves anticoagulant stability
J Thromb Haemost. 2007 Oct;5(10):2043-8. Epub 2007 Jul 31
Rombouts EK, Rosendaal FR, Van Der Meer FJ.

Non-compliance: the Achilles’ heel of anti-fracture efficacy
Osteoporos Int. 2007 Jun;18(6):711-9. Epub 2007 Jan 24
Seeman E, Compston J, Adachi J, Brandi ML, Cooper C, Dawson-Hughes B, Jönsson B, Pols H, Cramer JA.

Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women
J Bone Miner Res. 2007 Apr;22(4):509-19
Bolton-Smith C, McMurdo ME, Paterson CR, Mole PA, Harvey JM, Fenton ST, Prynne CJ, Mishra GD, Shearer MJ.

Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials
J Clin Endocrinol Metab. 2007 Apr;92(4):1415-23. Epub 2007 Jan 30
Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P.

How to select the doses of vitamin D in the management of osteoporosis
Osteoporos Int. 2007 Apr;18(4):401-7. Epub 2006 Dec 7
Bischoff-Ferrari HA.

Vitamin K in the treatment and prevention of osteoporosis and arterial calcification
Am J Health Syst Pharm. 2005 Aug 1;62(15):1574-81
Adams J, Pepping J

Calcium and vitamin D in preventing fractures. Vitamin K supplementation has powerful effect
BMJ 2005;331:108 (9 July), doi:10.1136/bmj.331.7508.108

Osteoporosis: the role of micronutrients
American Journal of Clinical Nutrition, Vol. 81, No. 5, 1232S-1239S, May 2005
Jeri W Nieves

Potential benefits of increased intakes of vitamin K for bone and vascular health
Eur J Nutr. 2004 Dec;43(6):325-35. Epub 2004 Feb 5
Vermeer C, Shearer MJ, Zittermann A, Bolton-Smith C, Szulc P, Hodges S, Walter P, Rambeck W, Stöcklin E, Weber P.

Vitamin K and bone health
Proc Nutr Soc. 2003 Nov;62(4):839-43
Bügel S.

The interaction of vitamins K and D in bone and vascular health
Vitamin K Research Unit, Haemophilia Centre, St Thomas’s Hospital, London.
Martin J Shearer

Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age
Calcif Tissue Int. 2003 Jul;73(1):21-6
Braam LA, Knapen MH, Geusens P, Brouns F, Hamulyák K, Gerichhausen MJ, Vermeer C.

A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation.
Am-J-Clin-Nutr. 2002 Nov; 76(5): 1055-60
Binkley, N C : Krueger, D C : Kawahara, T N : Engelke, J A : Chappell, R J : Suttie, J W.

Comparative efficacy and safety study of etidronate and alendronate in postmenopausal osteoporosis. effect of adding hormone replacement therapy
Joint Bone Spine. 2001 Oct;68(5):410-5
Cortet B, Béra-Louville A, Gauthier P, Gauthier A, Marchandise X, Delcambre B.

Role of vitamin K and K-dependent proteins in vascular calcification
Z Kardiol. 2001;90 Suppl 3:57-63
Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C.

Role of vitamin K and GLA proteins in the pathophysiology of osteoporosis and vascular calcification
Curr Opin Clin Nutr Metab Care. 2000 Nov;3(6):433-8
Shearer MJ.

Vitamin K intake and hip fractures in women
Am J Clin Nutr. 1999 Jan;69(1):74-9
Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA.

Vitamin K nutrition and osteoporosis
J Nutr. 1995 Jul;125(7):1812-21
Binkley NC, Suttie JW.

Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture
J Bone Miner Res. 1993 Oct;8(10):1241-5
Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD.

Disease Prevention. Osteoporosis. “VITAMIN K”. Research by Linus Pauling Institute, Oregon State University (1954 Nobel prize )

The role of vitamins in aging

Matrix GLA-eiwit met een te lage carboxyleringsgraad als risico factor voor aderverkalking